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Secrets and pies: the battle to get lab-grown meat on the menu | Stem cells

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Not a week goes by without Elliot Swartz receiving at least one request from researchers asking him where they can find cell lines (a cell culture developed from a single cell) for use in cellular agriculture – an essential tool for creating lab-grown meat. “One of the most important things that cell lines offer is that they enable researchers to just get started in this new field,” says Swartz, who works in New York as a senior scientist at the Good Food Institute (GFI) – a nonprofit focused on advancing cellular agriculture and bringing its products to our shelves and stomachs as quickly as possible. Helping researchers is a core part of his role. In the case of cell lines, however, there’s very little he can do.

Swartz’s response to the researchers is unfortunately always the same: at the moment, publicly available cell lines relevant for cellular agriculture don’t really exist. That doesn’t mean that they’re nowhere to be found. Upside Foods (previously Memphis Meats) has submitted several patents to protect cell lines it has developed, and companies such as Cell Farm Food Tech have built a business around selling cell lines for profit. Keeping discoveries behind closed doors is a pattern of behaviour found in private companies across the industry, which many believe is slowing down innovation.

Cellular agriculture is the use of animal cells or microbes to grow animal products, such as meat or milk, in bioreactors. The field gained prominence after Dutch scientist Mark Post unveiled the first cultured meat burger in 2013. Since then, cultured meats have been touted as a sustainable alternative to livestock farming, which is the leading cause of habitat destruction. Global demand for burgers and bacon is to increase over the coming decades, meaning more ecosystems will be bulldozed to accommodate the expanding market. This, in turn, will increase the risk of future pandemics, as biodiversity loss is linked to the emergence of new diseases. Moreover, efforts to cut carbon emissions will also fall short of Paris targets if we don’t reduce our meat consumption, according to a special report published by the Intergovernmental Panel on Climate Change in 2019.

Cellular agriculture gained prominence in 2013 when Prof Mark Post of Maastricht University, above, unveiled the first cultured meat burger.
Cellular agriculture gained prominence in 2013 when Prof Mark Post of Maastricht University, above, unveiled the first cultured meat burger. Photograph: Cultured Beef Website/EPA

There is some progress. In Singapore last year, Eat Just became the first cultured meat company to gain regulatory approval to sell its product. But many technological, social, and economic hurdles remain before our supermarkets are filled with a variety of cultured cutlets. To surpass these hurdles, organisations including the GFI are pushing for a more public exchange of data, tools and ideas. As it stands, most research in the field is done by private companies which seem keen to protect their intellectual property.

Swartz says the lack of publicly available cell lines “is a gatekeeper in getting people into the field, even though there’s a lot of interest,” adding that this isn’t really an issue in other industries. Scientists looking for stem cells for research or clinical purposes can go to the government-funded UK Stem Cell Bank, and across the Atlantic, the nonprofit American Type Culture Collection hosts a reserve of cell lines that are mainly open access. Although repositories like this do include animal cells, that doesn’t mean they’re suitable for generating meat.

What makes cell lines themselves so useful is that they are immortal and can multiply indefinitely, so they can be used as a standard model across the industry. “We’re not going to understand if our findings are true if different groups are using different cells with different features,” Swartz continues. “So cell lines are the first piece of the puzzle for getting cultivated meat to become an actual field of study.” The GFI is filling the cell-line-shaped hole in cellular agriculture by funding the creation of lines that will be openly accessible, and making a repository to store them in. Kerafast – a Boston-based bioresearch company – will maintain this repository. Researchers not involved with the GFI are welcome to deposit cell lines too, as are private companies; anyone looking to use the cells must pay a small fee to cover the costs of storing and maintaining them. So far, only one academic group has deposited a cell line. “The lines being worked on in academic groups are still in development, which is why we haven’t got that many yet,” Swartz says.


The reluctance of private companies to share their cell lines may in part be because of how they are financed – a GFI report found that of the $366m invested in cultured meat in 2020, only around $12m came from public sources. Controlling the vast majority of the capital in the industry means that the private sector can comfortably dictate the pace and direction of innovation, which the Breakthrough Institute’s food and agriculture analyst Saloni Shah sees as an issue. “With the government and public sector funding research you can set criteria and standards, and make sure the right kinds of technologies get funded so that the development of the sector accelerates and improves,” says Shah.

The complaint that governments need to start investing in more sustainable food options is echoed by Isha Datar, the executive director of New Harvest – another nonprofit focused on advancing cellular agriculture. She thinks one of the reasons the field lacks government funding is that it is a mix of tissue engineering, which is medically oriented, and food science. “Cellular agriculture is kind of homeless and so it falls in between the cracks of the existing pillars of funding and how we think about science being separated,” she says. Swartz also agrees that more public funding is needed, but he thinks it will only come after the technology has been scaled up. “‘Does this industry scale?’ is going to be the key to opening the floodgate for governments funding this technology,” he says. “Open source research is going to be really important for bringing new ideas on how to scale this technology or lower costs.”

Eat Just’s ‘no kill’ chicken
In December, Eat Just’s ‘no kill’ chicken became available at a Singapore restaurant. It is the first lab-grown meat granted regulatory approval. Photograph: Eat Just/AFP/Getty Images

Swartz also complains that secrecy is holding up the industry-wide adoption of other cheaper, more efficient materials. For example, all of the nutrients needed for animal cells to grow into chunks of meat are contained in the cell culture medium, but the industry standard foetal bovine serum is expensive, and must be extracted from the foetus of a slaughtered cow. Many startups claim to have developed alternatives, but they remain trade secrets. “Companies tend not to patent these things, because by patenting a cell culture medium you have to include everything that’s in there, which is open sourcing what the ingredients are,” says Swartz.

Even if the cell line problem were solved, there would still be technological hurdles holding the field back from large-scale commercialisation. Using computer modelling to address these hurdles and accelerate the intensification of cultured meat production is a central goal of the Cultivated Meat Modeling Consortium (CMMC).

Modelling is a useful tool that allows researchers to simulate experiments before entering a laboratory. This helps to save on time and resources. In order to run more complicated simulations, however, modellers first need data from simpler experiments that detail the fundamental biological processes behind cultured meat production – to understand the sum of the whole, we must first analyse the parts. “We’re experiencing quite some difficulty in getting the information we need to actually build models,” says Jaro Camphuijsen, a researcher associated with the CMMC. Private companies they work with have shown resistance to sharing data and running certain experiments. “We have been talking to a cultivated meat company quite a lot, and we often ask: ‘What happens if you do this experiment?’ The answer is usually: ‘We don’t know,’ and ‘We aren’t going to do that because the cells will die,’” Camphuijsen explains. But failed experiments, he says, can provide useful data points that often reveal more than successful tests. “Experiments that go wrong actually provide lots and lots of information if you want to find out how these tiny systems of cells are behaving.”

cellular meat
Companies say they can grow cellular meat in a lab but doubts remain about whether production can be scaled to create an affordable product. Photograph: Svetlana-Cherruty/Getty Images/iStockphoto

When asked to respond to accusations that industry secrets were slowing down innovation in the field, Uma Valeti, the CEO of Upside Foods, wrote in an email that the firm “kickstarted the cultured meat movement when we were founded in 2015. Without that, the industry wouldn’t be in the place it is today, where there are hundreds of companies, NGOs, academic groups and government institutions focusing on cultured meat, across every continent but Antartica.” She adds that Upside is “actively supportive of more open access research on cultured meat,” and it has “actively supported the development of public research institutions like the Cultured Meat Consortium”.

Responding to the same accusations, Robert E Jones, head of public affairs at Mosa Meat, wrote: “Few companies have done more than Mosa Meat to contribute to the open advancement of cellular agriculture.” He adds that Mosa “hoped the 2013 burger would trigger a moonshot level of public investment in research,” and that “there is something to be said for an innovation ecosystem that includes both private capital and public investments for a challenge as big as reforming the food system.”

The idea that governments need to start investing in more sustainable food options is echoed by Datar. She has concerns about a field that lacks an academic basis and publicly accessible information. “It means cellular agriculture is going to have to be more transparent than other industries,” says Datar. “I think we need a lot more data sharing and a lot more transparency if we are to create a better food system.” Will private companies heed this call for more transparency and build on their claims that they are supportive of more open access research, or will they follow the approach in other sectors where financial gain has been prioritised over societal benefits? Campaigners hope the answer is one that puts the planet before profit margins.

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Microsoft vulnerabilities down for 2021 • The Register

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Despite a record number of publicly disclosed security flaws in 2021, Microsoft managed to improve its stats, according to research from BeyondTrust.

Figures from the National Vulnerability Database (NVD) of the US National Institute of Standards and Technology (NIST) show last year broke all records for security vulnerabilities. By December, according to pentester Redscan, 18,439 were recorded. That’s an average of more than 50 flaws a day.

However just 1,212 vulnerabilities were reported in Microsoft products last year, said BeyondTrust, a 5 percent drop on the previous year. In addition, critical vulnerabilities in the software (those with a CVSS score of 9 or more) plunged 47 percent, with the drop in Windows Server specifically down 50 percent. There was bad news for Internet Explorer and Edge vulnerabilities, though: they were up 280 percent on the prior year, with 349 flaws spotted in 2021.

BeyondTrust commented that analysis had been simplified by Microsoft’s move to the Common Vulnerability Scoring System (CVSS), although an unfortunate side effect meant that security gurus can now determine the impact of administrative rights on critical vulnerabilities.

“From 2015 to 2020,” said the report, “removing admin rights could have mitigated, on average, 75 percent of critical vulnerabilities.”

It’s a very good point: keeping permissions to the bare minimum is excellent practice, although difficult to enforce.

The decline in vulnerabilities marks a change for Microsoft. In 2016, the count of vulnerabilities stood at 451, according to the report. By 2020 they had leapt to 1,268. A drop, even if only to 1,212, is a first. It’s just as well since between 2019 and 2020, there was a 48 percent rise in vulnerabilities year on year.

And the trendiest categories are…

The report also drilled into vulnerability categories. Topping the table with 326 and 588 vulnerabilities respectively were Remote Code Execution and Elevation of Privilege flaws, with the latter up from 559 in 2020. RCE was itself down in 2021 from 345 in the prior year.

Explaining the apparent explosion in Edge and Internet Explorer numbers (349 vulnerabilities up from 92 in 2020), BeyondTrust pointed to a consolidation in the browser market and a renewed focus on browser attacks as exploited plugins (such as Flash) were dropped and bug bounties made reporting vulnerabilities more financially attractive. It also pointed out that only six were critical (a record low).

The decline in Windows vulnerabilities was attributed to Microsoft’s efforts to improve the security architecture of its supported products, as was the fall in Windows Server holes. The move from security as an afterthought to something front and center is also a factor, even if it has taken a few iterations of operating systems.

That said, there were some spectacular holes in the company’s products during 2021. Last year’s Exchange Server vulnerabilities, for example, left many administrators scrambling to patch systems. 2021’s stability, from the standpoint of Microsoft’s vulnerabilities, must be considered alongside the rapid rises of previous years.

As the report authors note, simply patching the problems might not deal with the underlying issues. Removing admin rights and privileges also play a part in reducing the attack surface. ®

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Ford’s new car safety tech can automatically reduce vehicle speed

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The new Ford Geofencing Speed Limit Control system alerts a driver when the car breaks a speed limit – then slows down the vehicle.

Speed limit signs may soon be a thing of the past as Ford is now trialling connected vehicle technology that can automatically reduce a car’s speed in certain zones to improve road safety.

Up to 29pc of all road fatalities in Europe, depending on the country, are pedestrians and cyclists, according to a 2020 report by the European Transport Safety Council. Setting up speed limits in certain areas is one of the frontline measures to minimise road accidents.

Future Human

Now, US carmaker Ford is testing its new Geofencing Speed Limit Control system across two German cities, Cologne and Aachen, to see if the technology can help in making roads safer, preventing fines for drivers and improving the appearance of roadsides.

A geofence is a virtual parameter in a real-world area. It is often used by mobility companies and start-ups, such as Ireland’s Zipp Mobility, to identify and enforce low-speed zones in cities.

How does it work?

Ford’s new system uses geofencing technology to alert a driver through the dashboard when the vehicle enters an area with a designated speed limit. It then lowers the vehicle speed to match the limit automatically.

However, the driver can override the automated system and deactivate speed limit control at any time. They can also use the technology to set their own geofencing zones at speed as low as 20kmph.

“Connected vehicle technology has the proven potential to help make everyday driving easier and safer to benefit everyone, not just the person behind the wheel,” said Michael Huynh, manager of City Engagement Germany at Ford Europe.

“Geofencing can ensure speeds are reduced where – and even when – necessary to help improve safety and create a more pleasant environment.”

Ford already has in-built assistance technologies that help drivers ensure they are abiding by speed limits. However, the new geofencing speed limit control system is the first that can automatically reduce a vehicle’s speed without the driver’s intervention.

Eyes on the road

The year-long trial that runs until March 2023 is collaboration between the Ford City Engagement team, city officials in Cologne and Aachen, and Ford software engineers in Palo Alto, California.

Together with colleagues in Aachen, the Palo Alto engineers developed technology that connects the vehicle to the geofencing system for GPS tracking and data exchange.

Germany has more than 1,000 types of road signs, which can often confuse drivers and distract them from the road ahead. Geofencing technologies such as the new Ford system can help drivers stay focused.

“Our drivers should benefit from the latest technical support, including geofencing based assistant systems that enable them to keep to the speed limits and fully concentrate on the road,” said Dr Bert Schröer of AWB, a Cologne waste disposal company involved in the trial.

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Pushing Buttons: Why linking real-world violence to video games is a dangerous distraction | Games

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Welcome to Pushing Buttons, the Guardian’s gaming newsletter. If you’d like to receive it in your inbox every week, just pop your email in below – and check your inbox (and spam) for the confirmation email.

Sign up for Pushing Buttons, our weekly guide to what’s going on in video games.

Remember how, in the wake of yet more awful shootings in the US this month, Fox News decided to blame video games rather than, you know, the almost total absence of meaningful gun control? Remember how I said last week that the video-games-cause-violence “argument” was so mendacious and nakedly manipulative that I wasn’t going to dignify it with a response?

Well, here I am, responding, because the supposed link between video games and real-life violence is one of the most persistent myths that I’ve encountered over the course of my career, and it has an interesting (if also infuriating) history.

Many video games have violent content, just as many films and TV series have violent content (and of course many books, as anyone who has endured a Bret Easton Ellis novel will attest). And it makes intuitive sense that the interactivity of games – especially shooting games – might appear more troubling, from the outside, than passive media such as film. (I gotta say, though, that in 25 years of playing video games I have never seen a scene as violent or upsetting as, say, a Quentin Tarantino movie.)

But the idea that exposure to these violent games turns people into killers in real life is comprehensively false – and it deflects attention from the actual drivers of real-world violence, from inequality to access to firearms to online radicalisation. It is a very politically motivated argument, and one that makes me instantly suspicious of the person wielding it. The NRA, for instance, trots it out on the regular. Donald Trump, inciter of actual real-life violent riots, was fond of it too. Why might that be, I wonder?

First, the facts: there is no scientifically credible link between video games and real-life violence. A lot of the studies around this issue are, in a word, bad – small sample sizes, lab conditions that have no relation to how people engage with games in the real world – but the best we have show either no link at all between violent games and violent thoughts or behaviour, or a positive correlation so minuscule as to be meaningless. A review of the science in 2020, which looked at and re-evaluated 28 global studies of video games and violence, found no cumulative harm, no long-term effect, and barely even any short-term effect on aggression in the real world. It concluded that the “long-term impacts of violent games on youth aggression are near zero”.

This seems self-evident: video games have been a part of popular culture for at least 50 years, since Pong, and violent games have existed in some form since Space Invaders, though they’ve gotten more visually realistic over time. If video games were in some way dangerous – if they significantly affected our behaviour, our emotional responses – you would expect to have seen widespread, cross-cultural changes in how we act. That is demonstrably not the case. Indeed, overall, violent crime has been decreasing for more than 20 years, the exact period of time during which games have become ubiquitous. Though it would be unscientific to credit video games with that effect, you would think that if the generations of people who’ve now played Doom or Call of Duty or Grand Theft Auto were warped by it, we might be seeing some evidence of that by now.

It is true that some perpetrators of mass murders – such as the Columbine shooters – were fans of video games. But given that the great majority of teenagers are fans of video games, that doesn’t mean much. More often than a fixation on violent media – of all kinds – mass shooters display an obsession with weapons or explosives or real-life killers, an interest in extremist views, social ostracisation. These are not otherwise well-adjusted people suddenly compelled to real-world violence by a game, or a film, or a Marilyn Manson album.

The history of the “video games cause violence” argument goes back even further than video games themselves: it’s an extension of the panic that flares up whenever a new and supposedly morally abject form of youth culture emerges. In the 1940s, when New York’s mayor ordered 2,000 pinball machines to be seized so that he could performatively smash them up, it was arcades; during the satanic panic of the 1980s and beyond, it was metal music. Since the mid to late 90s, it’s been video games, and no amount of studies debunking any link between them and real-world violence seems to make a difference.

So why does this argument keep showing up? In short: because it’s an easy scapegoat that ties into older generations’ instinctive wariness of technology, screen time and youth culture, and it greatly benefits institutions like the NRA and pro-gun politicians to have a scapegoat. Whenever video games are implicated in a violent event, there is usually stunning hypocrisy on display. After the El Paso shooting in 2019, Walmart removed violent video game displays from its stores – but continued to sell actual guns. Fox News, the TV network that platforms Tucker Carlson and the great replacement theory with him, is happy to point out that the perpetrator of a mass shooting played video games, while remaining oddly quiet on the racist ideas that show up in these shooters’ manifestos.

I’m not saying that we shouldn’t examine video game violence at all, or question it. Does every game that involves sneaking up on enemies need a gratuitous neck-breaking animation when you succeed in overpowering a guard? Why do games so often resort to violence as the primary method of interaction with a virtual world? Do we really need more violent media – couldn’t we be playing something more interesting than another military shooter? These are valid and interesting questions. But they have nothing to do with real-world violence.

What to play

‘The most interesting anti-violent video game I’ve played’. This week, we recommend 2015’s Undertale
‘The most interesting anti-violent video game I’ve played’. This week, we recommend 2015’s Undertale Photograph: Toby Fox

Back in 1994, video game magazine Edge ended its review of Doom with this infamous line: “If only you could talk to these creatures, then perhaps you could try and make friends with them, form alliances… Now that would be interesting.” Nearly 30 years later, “talk to the monsters” jokes and memes still crop up, even if nobody remembers where it originally came from.

Turns out that reviewer had a point, though, as proved by 2015’s Undertale, probably the most interesting anti-violent video game I’ve played. In this lo-fi role-playing game, you get into fights with plenty of monsters, but instead of battering them into submission you can win them over by talking them down and showing them mercy, which is often the more difficult option. In most games, there’s no question about what you do when a monster turns up in your path: this one makes you interrogate yourself. I interpreted it at the time as social commentary on pacifism and community, and looking back, I don’t think that was too much of an overreach.

Available on: PC, PlayStation 4, Xbox One, Nintendo Switch
Approximate play time: 6-10 hours

What to read

  • I’m going to start with a book this time: Lost in a Good Game: Why We Play Video Games and What They Can Do For Us, by Pete Etchells. A researcher and lecturer in biological psychology, Etchells’ perspective on video games is both relatable and extremely well-informed. He looks at the evidence (or lack of evidence) behind all the most pervasive beliefs about video games, and in the end he makes the case that most of the effects that they have on individuals and society are actually positive. It’s a reassuring read that I often recommend to worried parents who don’t play games themselves.

  • Grand Theft Auto V, perhaps the poster child for morally bankrupt video games that supposedly corrupt the youth, has now sold 165 million copies, following its launch on PS5 and Xbox Series X earlier this year. This makes it one of the most popular entertainment products of all time in any medium, and yet strangely, in the nine years since it was released, we have not seen the emergence of roving gangs of teenagers looking to act out their chaotic GTA Online shootouts in real life. Funny that.

What to click

Gibbon: Beyond the Trees review – short, simple and lovely to play

Activision Blizzard’s Raven Software workers vote to form industry’s first union

Question Block

Will return next week. If you have anything you’d like me to answer, just email me on pushingbuttons@theguardian.com!

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