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RCSI scientists find potential treatment for secondary breast cancer

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An existing drug called PARP inhibitor can be used to exploit a vulnerability in the way breast cancer cells repair their DNA, preventing spread to the brain.

For a long time, there have been limited treatment options for patients with breast cancer that has spread to the brain, sometimes leaving them with just months to live. But scientists at the Royal College of Surgeons Ireland (RCSI) have found a potential treatment using existing drugs.

By tracking the development of tumours from diagnosis to their spread to the brain, a team of researchers at RCSI University of Medicine and Health Sciences and the Beaumont RCSI Cancer Centre found a previously unknown vulnerability in the way the tumours repair their DNA.

An existing kind of drug known as a PARP inhibitor, often used to treat heritable cancers, can prevent cancer cells from repairing their DNA because of this vulnerability, culminating in the cells dying and the patient being rid of the cancer.

Prof Leonie Young, principal investigator of the RCSI study, said that breast cancer research focused on expanding treatment options for patients whose disease has spread to the brain is urgently needed to save the lives of those living with the disease.

“Our study represents an important development in getting one step closer to a potential treatment for patients with this devastating complication of breast cancer,” she said of the study, which was published in the journal Nature Communications.

Deaths caused by breast cancer are often a result of treatment relapses which lead to tumours spreading to other parts of the body, a condition known as secondary or metastatic breast cancer. This kind of cancer is particularly aggressive and lethal when it spreads to the brain.

The study was funded by Breast Cancer Ireland with support from Breast Cancer Now and Science Foundation Ireland.

It was carried out as an international collaboration with the Mayo Clinic and the University of Pittsburgh in the US. Apart from Prof Young, the other RCSI researchers were Dr Nicola Cosgrove, Dr Damir Varešlija and Prof Arnold Hill.

“By uncovering these new vulnerabilities in DNA pathways in brain metastasis, our research opens up the possibility of novel treatment strategies for patients who previously had limited targeted therapy options”, said Dr Varešlija.

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YouTube removes more than 9,000 channels relating to Ukraine war | YouTube

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YouTube has taken down more than 70,000 videos and 9,000 channels related to the war in Ukraine for violating content guidelines, including removal of videos that referred to the invasion as a “liberation mission”.

The platform is hugely popular in Russia, where, unlike some of its US peers, it has not been shut down despite hosting content from opposition figures such as Alexei Navalny. YouTube has also been able to operate in Russia despite cracking down on pro-Kremlin content that has broken guidelines including its major violent events policy, which prohibits denying or trivialising the invasion.

Since the conflict began in February, YouTube has taken down channels including that of the pro-Kremlin journalist Vladimir Solovyov. Channels associated with Russia’s Ministries of Defence and Foreign Affairs have also been temporarily suspended from uploading videos in recent months for describing the war as a “liberation mission”.

YouTube’s chief product officer, Neal Mohan, said: “We have a major violent events policy and that applies to things like denial of major violent events: everything from the Holocaust to Sandy Hook. And of course, what’s happening in Ukraine is a major violent event. And so we’ve used that policy to take unprecedented action.”

In an interview with the Guardian, Mohan added that YouTube’s news content on the conflict had received more than 40m views in Ukraine alone.

“The first and probably most paramount responsibility is making sure that people who are looking for information about this event can get accurate, high-quality, credible information on YouTube,” he said. “The consumption of authoritative channels on our platform has grown significantly, of course in Ukraine, but also in countries surrounding Ukraine, Poland, and also within Russia itself.”

YouTube did not provide a breakdown of the taken-down content and channels but Mohan said much of it represented Kremlin narratives about the invasion. “I don’t have the specific numbers, but you can imagine a lot of it being the narratives that are coming from Russian government, or Russian actors on behalf of the Russian government,” he said.

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YouTube has an estimated 90 million users in Russia, although it no longer allows advertising on the platform in the country. The decision by YouTube’s parent company, Google, has drawn protests from Navalny, who said well-targeted ads helped counteract Kremlin propaganda.

“YouTube remains the largest video-sharing site up and running in Russia itself,” said Mohan. “So YouTube is a place where Russian citizens can get uncensored information about the war, including from many of the same authoritative channels that we all have access to outside of the country. We remain an important platform for Russian citizens themselves as this crisis continues to evolve.”

Last week, the Russian minister for digital development, Maksut Shadaev, said the country would not block YouTube, despite disputes over content that have resulted in the platform being fined in court for not removing banned videos.

Shadaev indicated that blocking Russia’s most popular social media platform would affect users. “We are not planning to close YouTube,” the minister said. “Above all, when we restrict something, we should clearly understand that our users won’t suffer.”

YouTube has also placed a worldwide ban on channels associated with Russian state media, including Russia Today and Sputnik. Facebook and Instagram are banned in Russia and access to Twitter has been restricted, in response to the platforms’ own bans on Russian state-owned media.

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Russian-backed rulers of Costa Rican hacktocracy? • The Register

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In brief The notorious Russian-aligned Conti ransomware gang has upped the ante in its attack against Costa Rica, threatening to overthrow the government if it doesn’t pay a $20 million ransom. 

Costa Rican president Rodrigo Chaves said that the country is effectively at war with the gang, who in April infiltrated the government’s computer systems, gaining a foothold in 27 agencies at various government levels. The US State Department has offered a $15 million reward leading to the capture of Conti’s leaders, who it said have made more than $150 million from 1,000+ victims.

Conti claimed this week that it has insiders in the Costa Rican government, the AP reported, warning that “We are determined to overthrow the government by means of a cyber attack, we have already shown you all the strength and power, you have introduced an emergency.” 

Experts who spoke to the AP said they doubt actual regime change is likely, or the goal; Emsisoft analyst Brett Callow told the newswire that the threats are simply noise, and not to be taken seriously.

Callow may be right: News unfolding late this week suggests that Conti has gone offline, and may be breaking into several subsidiary groups. Its political ambitions in Costa Rica may just be a distraction, albeit one that could also turn a tidy profit. 

NSA: Trust us, no post-quantum encryption backdoors

The NSA wants to ease everyone’s concerns now: Even though it’s been involved in the US government’s post-quantum encryption research, the spy agency won’t have a backdoor.

Speaking to Bloomberg while discussing the National Institute for Standards and Technology’s post-quantum encryption competition, NSA Director of Cybersecurity (and Christmas-tree hacker) Rob Joyce said the new standards being developed are so strong that “there are no backdoors.” 

That would be a departure from previous encryption standards, which the NSA is believed to have had ready access to – until foreign spies acquired a copy of the backdoor software for their own use. The Biden administration recently announced additional funding for post-quantum encryption research, which aims to develop a form of protecting sensitive data so secure that even a quantum computer couldn’t crack it. 

The US has been actively working to develop encryption standards able to stand up to quantum computers for some time; Joyce claimed to Bloomberg that the NSA has had its own post-quantum encryption algorithms for several years, but those aren’t part of the NIST competition or available to the public. 

Despite spending tens of millions to address the security problems posed by quantum computers, the NSA also readily admits that it has no idea when, or even if, quantum computers able to crack modern public key cryptography will be realized. 

Frustrated IT admin gets seven years for deleting company databases

A former database administrator from China who wiped out his employer’s financial records has been sentenced to seven years in prison as a result.

Han Bing, who managed databases for Chinese real estate brokerage Lianjia, allegedly used his administrator access and root privileges to log in to two of Lianjia’s database servers, and two application servers, where he wiped financial data and related applications that took the company’s entire finance system offline, said Chinese news sources. 

Bing was reportedly disgruntled with his employer. He repeatedly warned them of security flaws in Lianjia’s finance system but felt ignored and undervalued, Lianjia’s ethics chief testified in court. Bing’s actions directly cost the company around $27,000 to recover data and rebuilt systems, but that doesn’t include the impact of lost business.

Bing was caught when Lianjia questioned everyone with access to the financial systems who had permissions to do what Bing did, of whom there were only five. The company claims that Bing acted suspiciously when asked to present his laptop for inspection, refusing to provide his password and claiming privacy privileges. 

The company said it suspected none of the laptops would show traces of the attack, but wanted to see how those it questioned would react. Investigators were later able to recover logs that pointed to Bing’s laptop’s IP and MAC addresses, and crosschecking logs against security footage put Bing in the right place at the right time to be the guilty party.

Apple patches a whopping 98 separate vulnerabilities

Apple has had a busy week: In a series of security updates released Monday and Wednesday, the iMaker patched 98 separate vulnerabilities out of its various software platforms.

The updates in question cover most every bit of software Apple makes: WatchOS, iOS and iPad OS, macOS Monterey, Big Sur and Catalina, Xcode, tvOS, Safari and iTunes for Windows were all included. Most of the vulnerabilities are from the past few months, but one common vulnerability and exposure (CVE) number covered by the updates dates back to 2015.

A few of the vulnerabilities covered by this week’s glut of Apple patches were rolled out previously for one system, but not others, as was the case with CVE-2022-22674 and -22675, which were patched in macOS Monterey, but not older versions, in April. Those vulnerabilities were reportedly being actively exploited at the time. 

Malicious applications executing arbitrary code with kernel privileges appears to be the most common type of hole being closed in this round of patches, though some do stand out, like Apple Watch bugs that could let apps capture the screen and bypass signature validation.

On iOS, vulnerabilities patched include websites being able to track users in Safari private browsing mode, while macOS users are being protected against apps being able to bypass Privacy preferences and access restricted portions of the filesystem.

Russian-backing Chaos ransomware variant is pure destruction

Cybersecurity firm Fortinet has discovered a variant of the Chaos ransomware that professes support for Russia’s invasion of Ukraine, but appears to have no decryption key to rescue victims in Putin’s regime. 

The variant appears to have been compiled with Chaos’ GUI customization tool as recently as May 16, Fortinet said. The researchers said they’re unsure how the Chaos variant infects its victims, and said the variant doesn’t act any differently than typical Chaos ransomware. 

Like other forms of Chaos, it enumerates files on infected systems, and irrevocably damages any larger than around 2MB by filling it with random bytes. Anything smaller is encrypted, but recoverable with a key. Chaos also typically attacks commonly used directories like Desktop, Contacts, Downloads and Pictures, which are encrypted entirely. 

Here’s where this Chaos variant differs: It’s overtly political, and instead of offering contact info and a ransom demand, the malware simply says “Stop Ukraine War! F**k Zelensky! Dont [sic] go die for f**king clown,” along with a pair of links to sites claiming to belong to the Information Coordination Center, but offering no information otherwise. Files are also encrypted with a “f**kazov” extension, likely referring to the Ukrainian Azov Battalion.

Fortinet said that this Chaos variant appears unique in the sense it appears designed to be file-destroying malware. “This particular variant provides no such avenue as the attacker has no intent on providing a decryption tool … clearly, the motive behind this malware is destruction,” Fortinet said. 

The FortiGuard team behind the research warns that with its GUI, Chaos ransomware has become a commodity product, and it expects additional attacks of this variety to emerge. ®



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UCD-led research finds potential treatment for advanced eye cancer

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The team said their research could help improve treatment options for advanced uveal melanoma, which currently has a poor survival rate.

An international team of researchers led by University College Dublin (UCD) have uncovered a potential treatment for a type of cancer that effects the eye.

The researchers looked at uveal melanoma (UM), the most common form of eye cancer which is diagnosed in 50 to 60 people in Ireland each year. The team explained that UM begins in the middle layer of the eye, but if it spreads to the liver and other parts of the body, patients have a poor survival prognosis.

Future Human

In their study, the team aimed to uncover treatment options for the advanced stage of this eye cancer, as it becomes very difficult to treat once it has spread.

The researchers focused on a drug called ACY-1215, which is currently in clinical trials for other solid tumours and blood cancers. This drug belongs to a relatively new group of anticancer drugs called histone deacetylase inhibitors (HDACi).

“We wanted to understand how ACY-1215 works to prevent tumour cell growth and spread, in the context of UM,” said postdoctoral researcher Dr Husvinee Sundaramurthi.

Histones are proteins that provide structural support for DNA in cells, allowing DNA to be tightly packaged together. The researchers said these proteins act like a spool that a thread of DNA can wrap itself around.

In the study, the team used the drug ACY-1215 to interfere with the histones in advanced UM cells, to stop the processes involved in their survival and growth.

“We uncovered the particular molecules that may be involved in the anticancer effects the drug ACY-1215 has in advanced UM cells,” said study lead Prof Breandan Kennedy.

“This study will pave the way to look more closely at the benefits of using HDACi, specifically ACY-1215, as a suitable treatment option for advanced UM.”

Kennedy said that by understanding the therapeutic potential of the small molecules involved in the anticancer effects, researchers can improve UM patient care and create personalised treatment strategies.

The international research team involved groups from Spain, Sweden and Ireland. Funding was provided through grants from the Irish Research Council, in collaboration with Breakthrough Cancer Research, UCD’s TopMed10, Marie Skłodowska-Curie Actions CoFund Programme and Horizon 2020.

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