Connect with us

Technology

Goodbye silicone? A new era of breast reconstruction is on the horizon | Breast cancer

Voice Of EU

Published

on

Having an ice pack strapped to your chest – that’s how some describe the experience of taking a walk in cold weather when you have breast implants. Silicone only slowly reaches body temperature once out of the cold, so that icy feeling can persist for hours. As well as being uncomfortable, for breast cancer survivors it can be an unwelcome reminder of a disease they would rather put behind them.

Every year, 2 million people worldwide are diagnosed with breast cancer and the treatment often involves removing at least one breast. But most choose not to have their breasts reconstructed; in the UK, it is only about 30%. Now a handful of startups want to change that, armed with 3D-printed implants that grow new breast tissue before breaking down without a trace. “The whole implant is fully degradable,” says Julien Payen, CEO of the startup Lattice Medical, “so after 18 months you don’t have any product in your body.”

It could spell the end not only of cold breasts, but the high complication rates and long surgeries associated with conventional breast reconstruction. The first human trial of such an implant, Lattice Medical’s Mattisse implant, is scheduled to begin on 11 July in Georgia. Others will soon follow. “We expect to start clinical trials in two years’ time,” says Sophie Brac de la Perrière, CEO of another startup, Healshape.

“It’s exciting,” says Stephanie Willerth, professor of biomedical engineering at the University of Victoria, Canada, who is not involved with the companies. “As engineers, we’ve been playing with 3D printing for half a decade”, but having a clinical use that doctors recognise as useful for patients is key to getting the technology out there, she says.

But in a field fraught with difficult medical compromises, unequal access issues and expectations about what women want, the question is how big an impact the new technology will actually have.


Today, there are two main types of breast reconstruction: silicone implants and flap surgery. While implants are easy to install, flap surgery is a highly specialised business that requires a tissue “flap” being taken from the stomach, thigh or back. Surgeons often recommend flaps because, while there’s a lot of initial surgery and a longer recovery period, it gives a good, long-lasting result.

Silicone is still the most common choice. It is easy and simple, which appeals to cancer patients who either medically can’t have or mentally can’t face having tissue removed from another part of their body. But “it’s far from perfect”, says Shelley Potter, an oncoplastic surgeon at the University of Bristol and the Bristol Breast Care Centre. “It’s quite high risk. There’s a 10% chance of losing an implant.”

Healshape’s 3D-printed hydrogel implant
Healshape’s 3D-printed hydrogel implant, designed to be colonised by the patient’s fat cells over six to nine months. The company hopes to start trials in two years’ time. Photograph: Healshape

Silicone implants also require replacement every 10 or so years and they have had their fair share of scandals: the 2010s PIP scandal, in which a major implant manufacturer was found to have made its implants of dodgy silicone, and the 2018 Allergan scandal, in which popular textured implants were linked to an increased risk of a rare lymphoma. And as an American study from last year shows, it is mainly the idea of having that foreign object stuck inside your body that puts many off reconstruction altogether.

“So what we want to do,” says Brac de la Perrière, “is to give the benefits of the different solutions without the constraints.” In other words: the single, simple surgery of an implant, but without any lingering foreign material to cause trouble.

This can be achieved in different ways. Healshape uses a hydrogel to 3D-print a soft implant that will slowly be colonised by the person’s own fat cells, the initial batch of which is injected, while the implant disappears over six to nine months. The company CollPlant is developing something similar using a special collagen bioink, extracted from tobacco leaves it has genetically engineered to produce human collagen. “I think it will change the opinion of many patients,” says CEO, Yehiel Tal.

Lattice Medical has a different approach. Its implant is a 3D-printed cage made of a degradable biopolymer, in which they encase a small flap from underneath the breast area. This flap then grows to fill the cage with fat tissue, while the cage itself is absorbed by the body, ultimately leaving a regrown breast in its place.

Lattice Medical’s Mattisse implant
Lattice Medical’s Mattisse implant. Vascular adipose tissue is inserted into a bio-resorbable ‘tissue engineering chamber’, which degrades over 18 months. Trials are imminent. Photograph: Lattice Medical

Regrowing breasts using a cage has been shown to work in humans before, in a 2016 trial. However, it only worked in one of five women and the cages were not degradable. Andrea O’Connor from the University of Melbourne, Australia, who led the trial’s engineering team, hopes the new trial will address the problems raised in the first – for example, that patient responses can vary greatly. But if successful, it “would have the potential to help many women to achieve a superior reconstruction”, she says. Lattice Medical says its cage is an improvement because a flat base and larger pores help the tissue grow.

One big unknown is how much feeling the regrown breasts will have. A mastectomy usually means losing some sensation and, according to plastic surgeon Stefania Tuinder from the Maastricht University Medical Centre+ in the Netherlands, reconstruction affects it too. “From our data, it seems that implants have a negative effect on sensation, so the feeling in the skin is less than when you have only a mastectomy,” she says. In comparison, reconstruction from a flap with connected nerves can bring back some feeling within a few years.

Tuinder suspects the implant numbness is both because of nerve damage when the implants are inserted, and because the nerves can’t grow back once they are blocked by a lump of silicone. Whether that will also apply to the new implants remains to be seen, but since eventually there will be nothing to block the nerves, hopes are that sensation will be better.


Tissue engineered implants, however, are not the only recent innovations in the field. Many groups are working on perfecting a reconstruction technique using injections of the person’s own fat, boosted with extra stem cells to help the tissue survive. Medical professionals are still debating the safety and how the breasts hold up long term. In contrast to the new implants, the procedure might have to be done several times.

While any of these new techniques could result in something better than what’s currently on offer, Potter warns that we have a tendency to jump at new and shiny tech – an optimism bias. “We always think it’s going to be brilliant,” she says, but “we don’t want a situation like with vaginal mesh, where in 10 years’ time … we find out we have done something that isn’t helpful.”

Other solutions to the problems of reconstruction do exist. One is living without breasts, known as “going flat”. Contrary to the companies that think they can turn the reconstruction statistics around, people within the flat movement argue that if people were better informed, even more would opt out. “I reckon if [going flat] was given as an equal option,” says Gilly Cant, founder of the charity Flat Friends, “at least another 30-50% of women wouldn’t have [reconstruction].”

A Healshape scientist using software to determine the shape of an implant prior to 3D printing. The implants can be custom-made to suit the patient.
A Healshape scientist using software to determine the shape of an implant prior to 3D printing. The implants can be custom-made to suit the patient. Photograph: Healshape

At the moment, the guidance from the National Institute for Health and Care Excellence (Nice) says that doctors should be aware that some might not want reconstruction. But Cant says it is often presented to people as part of the treatment process. “It’s like, ‘OK, we need to do a mastectomy. Then you have chemo. Then you’ll have your radiotherapy and then we’ll do reconstruction.’ So women live for that reconstruction at the end,” she says. It comes to signal the finish line.

It is particularly contentious when only one breast is removed, because some might want the other taken off to feel and look symmetrical, rather than have a new one made. But according to Cant, many doctors don’t want to remove a healthy breast. Part of the doctors’ concern is that women will regret their decision, says Potter, but “women know what they want to do with their own bodies. We should help and support them to do what they want to do.”

Potter herself would like to see more of the ultimate alternative: not having a mastectomy in the first place. “There’s no evidence that mastectomy gives you better cancer outcomes than a breast-conserving operation,” she says. In this case, the tumour is removed but the breast is kept. For example, one of her patients had a breast reduction that removed her cancer while giving her breasts a lift. “She calls them her silver lining breasts.”


So even without tissue-engineered implants, there are enough options to make the choice a hard one. To help people choose, some charities pair up people considering a specific procedure with someone who has already been through it. At the charity Keeping Abreast, show and tell sessions give people the chance to ask the questions they might be uncomfortable asking their doctor and see the results for themselves.

But according to a 2018 report by the all-party parliamentary group on breast cancer, knowing what you want is not the same as having access to it. “There’s a massive postcode lottery,” says Potter. It stems from flap surgery being so involved that it often requires specialist plastic surgeons who can do minute surgery under a microscope. Many clinics don’t have such experts in-house and while the Nice guidance says people should still have the option, in practice it limits access.

The companies say this won’t be a problem with the new implants, because they are specifically designed to be easy to put in. Flap surgery can take from three to 12 hours depending on the flap, but insertion of Lattice Medical’s implant, for example, takes only one hour and 15 minutes. “It’s really accessible to all plastic surgeons,” says Payen.

This accessibility will no doubt be crucial in taking the new implants from a cool technology to something with real impact. But from Potter’s perspective, it’s just one potential piece in a big puzzle, not a techno-fix. The implants “would be an option for a lot of women”, she says. “But I think the main advance is all around access, proper information, giving women choice and hopefully reducing the number of mastectomies that we need.”

Source link

Technology

Lego releases Atari Video Computer System set • The Register

Voice Of EU

Published

on

Lego has followed up its Nintendo Entertainment System retro throwback with one celebrating the Atari Video Computer System (VCS).

The set, retailing at a heart-stopping $239.99 (£209.99 in the UK), is a non-functional replica of the iconic game console, although only the model with four switches rather than the six of others in the range. Not that those switches do an awful lot in Lego form.

In fact, compared to the cheaper Nintendo Entertainment System set (with all its twiddly technic bits and separate television), we’d have to describe the VCS set as a bit of a disappointment if it weren’t for the nostalgia factor.

The plastic bricks also fail to include a mock cartridge of the best game on the VCS, Combat. Asteroids, Centipede, and Adventure simply don’t cut it in comparison even with the reproduction of the hopelessly optimistic cover art so beloved by ’80s and ’90s designers and some neat Lego vignettes themed after the games.

Lego also opted to skip E.T. the Extra Terrestrial, described as the worst game ever. We can imagine an appropriate model for that example and the impact it had on the industry of the time.

Still, the 2,500-plus pieces will make for a fun build and includes a replica of the classic Atari joystick and a mini-fig scale 1980s room which pops up when the front is slid forward.

The price does seem high for what is effectively a plastic throwback to simpler times. Then again, other attempts to recreate that retro magic could cost you a lot more and potentially leave you without even a pile of plastic bricks to play with.

Or one could always take the plastic assembly and stick something like a Raspberry Pi (preloaded with an emulator) into it. Similar things were done with Lego’s Nintendo Entertainment System where the Technic guts of the television were removed and replaced with a Pi and an LCD screen to create something on which one can play games (ROM ownership notwithstanding).

Youtube Video

It is a shame that Lego did not see fit to include a television with the Atari VCS in the way it did with the NES, and also limited interaction to a pop-up 1980s room and some switches. However, the design looks good and is a reminder of an age when sticking something that looked like wood on the front of the console and squeezing games into kilobytes rather than gigabytes was state of the art.

Otherwise there are many examples of the VCS that can be had on various auction sites for considerably less than Lego’s asking price that are a good deal more interactive. ®

Source link

Continue Reading

Technology

4 reasons hybrid working looks set to stay for young professionals

Voice Of EU

Published

on

From priorities to practicalities, Dr Amanda Jones of King’s College London explains why hybrid working may be here to stay and outlines the pitfalls that younger employees will need to avoid.

Click here to visit The Conversation.

A version of this article was originally published by The Conversation (CC BY-ND 4.0)

We’re in the middle of a remote working revolution. In the UK, though remote working was slowly growing before the pandemic, in 2020 the number of people working from home doubled.

While this rapid rise can be explained by Covid lockdowns, a recent survey my colleagues and I conducted with 2,000 London workers found that six in 10 employees still regularly work from home despite restrictions no longer being in place. And most don’t want that to change.

Findings from other parts of the world similarly point to a substantial increase in the number of work days being undertaken from home.

For young professionals, the shift has been particularly significant. Before the pandemic, employees in their 20s were by far the least likely to work from home.

In 2022, 64pc of 16 to 24-year-olds we surveyed reported working at home for at least part of the week. This figure is in line with 25 to 49-year-olds (65pc) and in fact higher than for people over 50 (48pc).

Other research also shows that young professionals now engage in hybrid working – dividing their time between their home and their workplace – and may prefer this model to being in the office full time.

US and European data shows that around four in 10 jobs can be conducted from home. But this figure may be higher if we consider that some jobs could be at least partly done from home. In particular, jobs in finance and insurance, information and communication and education are among the most conducive to being performed remotely.

Technologies which support remote working, such as Zoom and Slack, have been available for a number of years. While the pandemic has served as a catalyst for the rise in remote working among younger employees, I would argue that other factors have also contributed to this shift – some of which were already evident before the pandemic.

Importantly, each of these factors suggest this change to the way young professionals work is here to stay.

1. Priorities

Evidence suggests that even before the pandemic, young people were becoming more focused on their own goals, wanted greater flexibility and control, and sought a better work-life balance compared with previous generations. The reasons for this may be related to the changing nature of organisations and careers, which I’ll discuss later.

Our own and other research indicates that remote working, especially working from home (as opposed to, say, at client sites), can boost feelings of flexibility and control and enhance work-life balance. So working remotely could help younger people achieve these goals in a way that traditional working arrangements can’t.

In fact, research indicates that many young people would now rather switch jobs than compromise on the flexibility they gain from hybrid working. So for employers, supporting hybrid working may be necessary to attract and retain the best employees.

2. Practicalities

Across all age groups, participants in our research picked avoiding the commute as the biggest benefit of working remotely. While this has long been a recognised advantage of remote working, it’s important to note that we surveyed London workers – and the commute may be less of an issue for people in other places.

Aside from the time and hassle involved in commuting, travelling to work every day can be expensive. The cost of working in the office goes up if you also factor in lunches, coffees and after-work social activities.

This may be difficult for younger people – who are contending with the rising costs of living, often on lower salaries – to manage. Working remotely can help reduce spending, making it an attractive option – and even a potential lifeline – for younger employees.

3. Career trajectories

Studies show that a move towards less hierarchical, more efficient and flexible organisations results in a “new deal” of employment. Employers no longer guarantee job security and progression for employees, but gain their commitment by providing opportunities – including training programmes – that enhance their employability.

The onus then moves to employees to manage their own career progression, which remote working may help them with. For example, we know working from home can reduce distractions and improve productivity.

Taken with the commuting time saved, young professionals may have more time to dedicate to development opportunities, such as studying for additional qualifications. This could increase their attractiveness in the job market.

Indeed, young professionals seem to be the most likely to switch jobs. If they don’t expect to remain with an organisation long term, they may be less motivated to build strong relationships with colleagues and managers, and unwilling to put their own goals aside for those of the organisation.

4. Managers’ behaviour

Research shows many more managers now work remotely compared with before the pandemic. This change has two important effects.

First, managers who work remotely are likely to find it harder to stop juniors from doing the same. Managers’ ability to monitor and develop their junior staff in person, a common reason for prohibiting remote work in the past, is also reduced if managers are away from the office themselves.

Second, as more managers work remotely, younger employees may feel more confident that doing so won’t prevent them achieving success. Managers serve as role models to junior employees and evidence shows that younger professionals seek success by copying role models’ behaviour.

Avoiding the pitfalls of hybrid working

Despite the positives, younger employees, with comparatively limited experience and networks, may face disproportionately negative outcomes from remote working in terms of recognition, development and networking opportunities.

So if you’re a young professional working remotely, how can you avoid the pitfalls of hybrid working?

Setting your own goals can keep motivation and performance high. Meanwhile, proactively communicating your challenges and achievements to senior and peer-level colleagues can ensure that you receive guidance and recognition.

It’s a good idea to plan some of your time in the office to coordinate with team members or managers. At the same time, it’s useful to try to schedule office visits on different days of the week. This can help maintain key relationships but also help build networks through bumping into colleagues you don’t necessarily work as closely with.

Finally, upping attendance at external conferences and events could increase your value to the organisation through encouraging innovation and fresh ideas, while keeping you aware of external employment opportunities.

The Conversation

By Dr Amanda Jones

Dr Amanda Jones is a lecturer in organisational behaviour and human resource management at King’s College London.

10 things you need to know direct to your inbox every weekday. Sign up for the Daily Brief, Silicon Republic’s digest of essential sci-tech news.

Source link

Continue Reading

Technology

Kids’ tech: the best children’s gadgets for summer holidays | Gadgets

Voice Of EU

Published

on

With the long school summer holiday well under way, you may need a bit of help keeping the kids entertained. From walkie-talkies and cameras to tablets, robot toys and fitness trackers, here are some of the best kid-aimed tech to keep the little (and not-so-little) ones occupied.

Robot toys

Sphero Mini – about £50

Sphero Mini robotic ball.
Sphero Mini robotic ball. Photograph: Bryan Rowe/Sphero

Lots of tech toys are fads but my longtime favourite has stood the test of time as a modern update to remote control fun. Sphero is a ball you control using a smartphone or tablet, and has hidden depths, with games and educational elements also available.

The mini Sphero ball is a lot of fun to drive around and small enough that overexuberant indoor excursions won’t result in broken furniture and scuffed-up paintwork. The Sphero Play app has games, while the Sphero Edu app is great at fostering creative learning.

Kids or big kids can learn to program, follow examples, get the robot to do all sorts of things, or go deeper and write some code for it in JavaScript. Higher-end versions such as the £190 BOLT take the educational elements to the next level, too.

Tablets

Amazon Fire 7 Kids – about £110

Amazon Fire 7 Kids edition tablet.
Amazon Fire 7 Kids edition tablet. Photograph: Amazon

If you would rather not lend your precious breakable phone or iPad to your little ones, Amazon’s practically indestructible Kids edition tablets could be just the ticket.

The cheapest and smallest Fire 7 has just been updated and is available in a range of bright-coloured cases with a pop-out stand. If your offspring do manage to break it, Amazon will replace it for free under its two-year “worry-free” guarantee.

It does all the standard tablet things such as movies, apps, games, a web browser if you want it, and parental controls to lock it, set time limits and age filters. There’s even an option restricting access to curated child-safe sites and videos but it doesn’t have access to the Google Play store, only Amazon’s app store.

The Kids edition comes with a one-year subscription to Amazon Kids+ (£3 to £7 a month afterwards), which is a curated collection of child-friendly text and audio books, movies, TV shows and educational apps.

The larger £140 Fire HD 8 and £200 Fire HD 10 are available in Kids versions, too, if you want something bigger, or Amazon’s new Kids Pro tablets start at £100 with additional features aimed at school-age children.

Alternatives include LeapFrog’s various educational tablets, which are fine for younger children, or hand-me-down or refurbished iPads (from £150) in robust cases, which can be locked down with some parental controls.

Cameras

VTech Kidizoom Duo 5.0 – about £39

VTech Kidizoom Duo 5.0 kids’ camera in pink.
VTech Kidizoom Duo 5.0 kids’ camera in pink. Photograph: VTech

Before the advent of smartphones, standalone cameras were the way we visually documented our lives, and they still can be a bit of creative fun and inspiration for kids.

The VTech Kidizoom Duo 5.0 is a “my first digital camera” of sorts made of rugged plastic and simple in operation, which VTech reckons is suitable for three- to nine-year-olds. It captures 5MP photos of reasonable quality and can shoot from the back for selfies, too, all viewable on a 2.4in screen.

The optical viewfinder helps them line up the shot, which they can transform with fun filters and effects. It even shoots video, too. The kid-centric nature of it might turn off older children but every award-winning photographer has to start somewhere before the smartphone takes over.

It needs an SD card for storage and takes four AA batteries at a time, and chews through them fast, so buy some rechargeables to help save money and the planet.

For older children, rugged and waterproof action cams could be the way to go, shooting video and photos. Budget no-brand cams cost from about £80 but secondhand or refurbished models from the big boys such as GoPro and DJI go for about £100 and on eBay and elsewhere.

Fitness trackers

Garmin Vivofit Jr 3 – from about £55

Garmin Vivofit Jr 3 Star Wars edition.
Garmin Vivofit Jr 3 Star Wars edition. Photograph: Garmin

Your child may not need any encouragement to tear about the place but if you are after a gadget to “gamify” and reward their activity – as well as giving them a smartwatch-esque gadget to play with – the Garmin Vivofit Jr 3 could be a winner for ages four and up.

Its watch-like form comes in various themes and designs, including with various Star Wars, Marvel and Disney characters, with custom watchfaces to choose from. The user-replaceable coin-cell battery lasts a year, so you don’t have to worry about charging it. Water-resistance to 50 metres means swimming should be no problem either.

It tracks steps, activity and sleep with motivational messaging. It has mini games to play once your child has hit their goals, and can all be managed from a parent’s phone or tablet, so you can keep an eye on their data. Parents can even set goals, competitions with their own activity levels, chore reminders and tasks that can earn virtual coins for them to trade for rewards with you.

It is button-operated rather than touchscreen, and the backlight doesn’t stay on long to preserve the battery.

If you are a user of Google’s Fitbit trackers yourself, then the firm’s Ace 3 (£50) means you can compete on activity, but it needs charging every seven or so days. Other cheaper adult-focused fitness trackers such as the Xiaomi Mi Smart Band 6 (about £29) may be better for older children.

Walkie-talkies

Motorola T42 Talkabout – about £35 for three

Motorola Talkabout T42 two-way radios.
Motorola Talkabout T42 two-way radios. Photograph: Motorola Solutions

Walkie-talkies are a great replacement for phones, allowing kids and big kids to keep in touch without fear of fees or smashed screens.

There are plenty of child-centric options available with various character themes but basic units usually work better. Motorola’s T42 Talkabout comes in various colours and multipacks.

They are simple to set up, with a pairing button and multiple channel selection to find a clear one. Once going, just push to talk, even over long distances. Their quoted 4km range might be a bit ambitious but they should be good for at least 500 metres in urban environments, or much further in the open air.

They take three AAA batteries each, which last about 18 hours of talking or roughly three to four days in active use, so you might need a small army of rechargeable batteries.

They have a belt clip and loop for hooking to a carabiner (metal loop) or similar, and are fairly rugged, too, so should survive being launched across a room or two.

Nestling’s camouflage walkie-talkies (about £26) are also a popular choice but there are lots of choices under £30 available on the high street.

Source link

Continue Reading

Trending

Subscribe To Our Newsletter

Join our mailing list to receive the latest news and updates 
directly on your inbox.

You have Successfully Subscribed!